The U.S. Food and Drug Administration (FDA) announced today that it is proposing a new rule to stop the use of an ingredient in popular over-the-counter (OTC) cold and allergy medications. The rule would remove oral phenylephrine from the administration’s list of approved active ingredients that can be used in OTC drugs like NyQuil (PG), Benadryl (JNJ), and Mucinex. Following a review of available data, the agency determined that phenylephrine, when taken orally, does not actually work as a nasal decongestant.